1shoppingcart seems to be the best for all in one service to run a real launch. I'm not an affiliate, but recently had them recommended to me. I checked them out and they seem to be able to provide whatever you will need to be successful with a big launch. You will need the Professional version to be able to manage affiliates.
They also have an auto responder service and you can switch over your databases if you chose to.
It's worth checkin out.
I would also like to know of any other options worth looking at, if anyone else wants to chime in.
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