For my most recent launch, I decided to give out 10% bonus for certain tiers, but in prizes instead of cash. So if somebody sold $10k in product, then I tried to make the corresponding prize equal to $1k.
And Curtis, you're right about it tailoring to the big guys, but you'd be surprised how much prizes can motivate the "little guys" when they are attainable. That's why I put my first bonuses close in number - prizes for 1 sale, 3 sales, five sales, ten sales, then I jump up to twenty, thirty, fifty...
That way, even the little guys can get in on it, and they think, "If I can just make two more sales..."